脊髓損傷（SCI）研究的利器
(MASCIS Impactor,NYU Impactor)脊髓損傷撞擊器是設(shè)計(jì)用來(lái)為大小鼠施加可重復(fù)的標(biāo)準(zhǔn)脊椎撞擊。已經(jīng)開(kāi)發(fā)應(yīng)用超過(guò)十年，它是嚙齒類(lèi)動(dòng)物脊髓損傷模型的一部分，已經(jīng)有超過(guò)100個(gè)實(shí)驗(yàn)室在使用它。另外，*近超過(guò)50%的關(guān)于脊髓損傷研究文獻(xiàn)使用的是MASCIS撞擊器。大部分儀器的建議操作程序是源自于Multicenter Animal Spinal Cord Injury Study(MASCIS)模型和實(shí)際工作經(jīng)驗(yàn)。
現(xiàn)有MASCIS撞擊器現(xiàn)在是它的第三代產(chǎn)品，與以前的產(chǎn)品相比已經(jīng)有很多方面的改進(jìn)提高?，F(xiàn)有兩個(gè)型號(hào)的撞擊器。電腦版撞擊器(Model I)可以記錄數(shù)據(jù)。同時(shí)也可以使用基本版撞擊器(The Rutgers Impactor,Model II)僅進(jìn)行撞擊， 不記錄數(shù)據(jù)。
電腦版撞擊器可以**測(cè)量一個(gè)10克的小棒的運(yùn)動(dòng)情況，這個(gè)小棒從12.5mm，25mm，50mm高處落到術(shù)后暴露的脊髓T9-10處。另外設(shè)備還可以測(cè)量撞擊位置脊柱的運(yùn)動(dòng)。顯示墜落小棒的軌跡，并測(cè)量撞擊速度（ImpV），脊髓壓縮距離（Cd），脊髓壓縮時(shí)間(Ct)，脊髓壓縮率(Cr)。這些撞擊參數(shù)本身是相關(guān)的，同時(shí)與其它的脊髓損傷數(shù)值如組織Na，K濃度，運(yùn)動(dòng)恢復(fù)locomotor recovery(BBB 評(píng)分)也是相關(guān)的。
大小鼠的撞擊都需要一個(gè)固定系統(tǒng)(Clamping systems)。同時(shí)還需要一個(gè)CS-tie。
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Model II
Model I
參考文獻(xiàn)
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