尿調(diào)節(jié)蛋白抗體
規(guī)格：1mg/1ml
英文名： Uromucoid
別名： Uromodulin; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; MGC14034; TAMM-HORSFALL; THGP; THP; UMOD; urehr4; Uromodulin; uromucoid; UROM_MOUSE; UROM_HUMAN.
分子量： 68kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Monoclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Uromucoi
交叉反應(yīng)：Human, Mouse, Rat, Cow,
尿調(diào)節(jié)蛋白抗體細(xì)胞定位：細(xì)胞膜
產(chǎn)品介紹：background: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia,尿調(diào)節(jié)蛋白抗體 gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq] Function: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. Subcellular Location: Apical cell membrane; Lipid-anchor, GPI-anchor.尿調(diào)節(jié)蛋白抗體 Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Note=Only a small fraction is sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Uromodulin, secreted form: Secreted. Post-translational modifications: N-glycosylated. Similarity: Contains 3 EGF-like domains. Contains 1 ZP domain. Gene ID: 7369 Database links: Entrez Gene: 7369 Human Omim: 191845 Human SwissProt: P07911 Human SwissProt: Q5R5C1 Orangutan Unigene: 654425 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿調(diào)節(jié)蛋白抗體產(chǎn)品應(yīng)用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Mouse
外觀： Lyophilized or Liquid
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