GLP-1單克隆抗體

規(guī)格：1mg/1ml

英文名： GLP-1(1G9)

別名： GCG; GLP 1; glucagon; Glucagon like peptide 1; GRPP; GLP-1(7-36); GLP-1(7-37); Oxyntomodulin; OXM; OXY; GLUC_HUMAN.

分子量： 21kDa

儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Monoclonal

亞型：IgG

純化方法：affinity purified by Protein G

**原：KLH conjugated synthetic peptide derived from human GLP-1

交叉反應：Human, Mouse, Rat,

GLP-1單克隆抗體細胞定位：分泌型蛋白

產(chǎn)品介紹：background: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in thesuppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin. Belongs to the glucagon family. Function: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia.GLP-1單克隆抗體 Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life Subcellular Location: Secreted. Tissue Specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Post-translational modifications: GLP-1單克隆抗體Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas. Similarity: Belongs to the glucagon family. Gene ID: 2641 Database links: Entrez Gene: 2641 Human Entrez Gene: 14526 Mouse Entrez Gene: 24952 Rat Omim: 138030 Human SwissProt: P01275 Human SwissProt: P55095 Mouse SwissProt: P06883 Rat Unigene: 516494 Human Unigene: 45494 Mouse Unigene: 54383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰高血糖素（Glucagon）在糖代謝和體內(nèi)平衡中起重要作用，通過釋放糖原和糖酵解調(diào)節(jié)血糖。作為反調(diào)節(jié)**的胰島素，當血糖升高時，胰島素可誘導低血糖。 胰高血糖素樣肽-1（Glucagon-like peptide-1, GLP-1）是一個具有強的刺激糖依賴的胰島素釋放的肽，在胃運動性和抑制血糖水平上起重要作用。還可能參與外周組織糖的控制，不依賴胰島素的作用。具有促進腸上皮生長等作用。GLP-1屬于胰高血糖素家族成員。

GLP-1單克隆抗體產(chǎn)品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：腫瘤  心血管  **學  神經(jīng)生物學  信號轉(zhuǎn)導  生長因子和**  糖尿病  ***病  新陳代謝  

儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來源： Mouse

外觀： Lyophilized or Liquid

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