巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體
規(guī)格：1mg/1ml
英文名： Nestin
別名： ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_HU
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nestin
交叉反應(yīng)：Human,
巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體細(xì)胞定位：
產(chǎn)品介紹：background: There are a certain number of neural stem cells, which can be potentially differentiated into the neurons or neuroglia, in the ***** mammalian brain. These neural precursors are located in the subependymal cell layer of the ventricle. Those precursors isolated from embryonic brain can be divided and differentiated into the neurons and glia in vitro and this is regulated by a series of growth-factor actions. Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor 巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Subunit: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity). Tissue Specificity: CNS stem cells. Post-translational modifications: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. Similarity: Belongs to the intermediate filament family. 巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體Gene ID: 10763 Database links: Entrez Gene: 10763 Human Entrez Gene: 18008 Mouse Entrez Gene: 25491 Rat Omim: 600915 Human SwissProt: P48681 Human SwissProt: Q6P5H2 Mouse SwissProt: P21263 Rat Unigene: 527971 Human Unigene: 331129 Mouse Unigene: 9701 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 結(jié)構(gòu)蛋白（Structural Proteins） Neural Stem Cell Marker (神經(jīng)干細(xì)胞標(biāo)志物) 在動物體早期發(fā)育過程中，**神經(jīng)系統(tǒng)發(fā)育尤為重要 。Nestin是一種中等纖維蛋白，它在哺乳動物神經(jīng)前體細(xì)胞中表達(dá)較高，目前已被廣泛用于神經(jīng)前體細(xì)胞的重要標(biāo)志分子。研究Nestin的表達(dá)調(diào)控規(guī)律，將有助于人們認(rèn)識神經(jīng)前體細(xì)胞的生物特性。此抗體還表達(dá)**神經(jīng)系統(tǒng)干細(xì)胞及神經(jīng)上皮細(xì)胞。
巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 干細(xì)胞 細(xì)胞類型標(biāo)志物 腫瘤細(xì)胞生物標(biāo)志物
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險(xiǎn)，建議您在購買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會員自行發(fā)布，若信息的真實(shí)性、合法性存在爭議，平臺將會監(jiān)督協(xié)助處理，歡迎舉報(bào)