胰島素樣生長(zhǎng)因子-II抗體
規(guī)格：1mg/1ml
英文名： IGF II
別名： C11orf43; FLJ22066; FLJ44734; IGF 2; IGF II; IGF-II; IGF2; IGF2_HUMAN; IGFII; INSIGF; insulin like growth factor 2 (somatomedin A); Insulin like Growth Factor 2; Insulin like growth factor II; Insulin
分子量： 7.4kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGF II 3
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
胰島素樣生長(zhǎng)因子-II抗體細(xì)胞定位：分泌型蛋白
產(chǎn)品介紹：background: The IGF2 gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is expressed only from the paternally inherited allele and is an imprinted gene which is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Insulin Like Growth Factor-2 (IGF-2) is a polypeptide growth factor, which stimulates the proliferation of a wide range of cell types. Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens 胰島素樣生長(zhǎng)因子-II抗體for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Subcellular Location: Secreted. Post-translational modifications: O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99. DISEASE: Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:180860]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety o胰島素樣生長(zhǎng)因子-II抗體 minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Similarity: Belongs to the insulin family. Gene ID: 3481 Database links: Entrez Gene: 3481 Human Entrez Gene: 281240 Cow Entrez Gene: 16002 Mouse Entrez Gene: 24483 Rat Omim: 147470 Human SwissProt: P07456 Cow SwissProt: P01344 Human SwissProt: P09535 Mouse SwissProt: P01346 Rat Unigene: 272259 Human Unigene: 718427 Human Unigene: 3862 Mouse Unigene: 118681 Rat Unigene: 224460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰島素樣生長(zhǎng)因子2(IGF-2又稱Somatomedin A)，是一種生長(zhǎng)調(diào)節(jié)**，由肝分泌并入血液循環(huán)的中性多肽，具有調(diào)節(jié)生長(zhǎng)和代謝、胰島素樣及促細(xì)胞分裂的活性，為主要的胚胎生長(zhǎng)因子。
胰島素樣生長(zhǎng)因子-II抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：**學(xué) 發(fā)育生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和** 糖尿病
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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