骨橋蛋白/分泌型磷蛋白1抗體
規(guī)格：1mg/1ml
英文名： osteopontin
別名： BNSP; Bone sialoprotein 1; BSP I; BSPI; Early T lymphocyte activation 1; ETA 1; ETA1; MGC110940; Nephropontin; OPN; Osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion p
分子量： 34kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OPN
交叉反應(yīng)：Human, Pig, Cow, Sheep,
骨橋蛋白/分泌型磷蛋白1抗體細胞定位：分泌型蛋白
產(chǎn)品介紹：background: Osteopontin is the principal phosphorylated glycoprotein of bone and is expressed in a limited number of other tissues including dentine. Osteopontin is produced by osteoblasts under stimulation by calcitriol and binds tightly to hydroxyapatite. It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. Osteopontin is overexpressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma. Function: Binds tightly to hydroxyapatite. 骨橋蛋白/分泌型磷蛋白1抗體Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity). Subunit: Ligand for integrin alpha-V/beta-3. Subcellular Location: Secreted. Tissue Specificity: Bone. Found in plasma. Similarity: Belongs to the osteopontin family. Gene ID: 6696 Database links: Entrez Gene: 6696 Human Entrez Gene: 20750 Mouse Entrez骨橋蛋白/分泌型磷蛋白1抗體 Gene: 25353 Rat Omim: 166490 Human SwissProt: P10451 Human SwissProt: P10923 Mouse SwissProt: P08721 Rat Unigene: 313 Human Unigene: 288474 Mouse Unigene: 8871 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 信號傳導(dǎo)（Signaling Intermediates） 骨橋蛋白(osteopontin，OPN)是一種含精氨酸—甘氨酸—天冬氨酸(Arg-Gly-Asp，RGD)的分泌型糖基化磷蛋白，已歸類于細胞外基質(zhì)(extracellular matrix，ECM)蛋白。 OPN既是細胞因子，又是細胞黏附分子.又稱：分泌性磷酸化蛋白質(zhì)1 OPN*初是從骨組織分離的，而后在上皮細胞、胃腸道的分泌物、腎、甲狀腺、睪丸以及一些腫瘤細胞里都陸續(xù)的發(fā)現(xiàn)了OPN的表達。在生殖方面，OPN在分泌期**內(nèi)膜上皮細胞、侵襲的滋養(yǎng)細胞、蛻膜細胞中表達。
骨橋蛋白/分泌型磷蛋白1抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：**學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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