乙型肝炎病毒X蛋白相互作用蛋白
規(guī)格：1mg/1ml
英文名： HBXIP
別名： HBV X interacting protein; HBX interacting protein; Hepatitis B virus X interacting protein; MGC71071; XIP; HBXIP_HUMAN.
分子量： 9.6kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HBXIP (5
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
細(xì)胞定位：細(xì)胞漿
乙型肝炎病毒X蛋白相互作用蛋白產(chǎn)品介紹：background: HBXIP (Hepatitis B virus X interacting protein) complexes with the C-terminus of hepatitis B virus X protein (HBx) and down-regulates hepatitis B virus (HBV) replication. When complexed to BIRC5, it interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Function: When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. Subunit: Homodimer (Probable). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX 乙型肝炎病毒X蛋白相互作用蛋白C-terminus. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection. Post-translational modifications: Phosphorylated upon DNA damage乙型肝炎病毒X蛋白相互作用蛋白, probably by ATM or ATR. Similarity: Belongs to the HBXIP family. Database links: Entrez Gene: 10542 Human Entrez Gene: 68576 Mouse Entrez Gene: 295357 Rat Omim: 608521 Human SwissProt: O43504 Human SwissProt: Q9D1L9 Mouse Unigene: 439815 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乙型肝炎病毒X蛋白相互作用蛋白產(chǎn)品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 **學(xué) 細(xì)胞凋亡 **及病毒
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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