糖皮質(zhì)**誘導(dǎo)亮氨酸拉鏈蛋白抗體

規(guī)格：1mg/1ml

英文名： GilZ

別名： Delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive peptide; Dsip1; Dsipi; GILZ; Glucocorticoid-induced leucine zipper protein; hDIP; Protein DIP; T22D3_HUMAN; TSC-22-like protein; TSC-22-

分子量： 23kDa

儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human GilZ/Til

交叉反應(yīng)：Human, Mouse, Rat,

細胞定位：

糖皮質(zhì)**誘導(dǎo)亮氨酸拉鏈蛋白抗體產(chǎn)品介紹：background: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Subunit: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Tissue Specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem 糖皮質(zhì)**誘導(dǎo)亮氨酸拉鏈蛋白抗體cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. Similarity: Belongs to the TSC-22/Dip/Bun family. Gene ID: 1831 Database links: Entrez Gene: 1831 Human Entrez Gene: 14605 Mouse Entrez Gene: 100171736 Orangutan Entrez Gene: 100517321 Pig Entrez Gene: 83514 Rat糖皮質(zhì)**誘導(dǎo)亮氨酸拉鏈蛋白抗體 Omim: 300506 Human SwissProt: Q99576 Human SwissProt: Q9Z2S7 Mouse SwissProt: Q5RED5 Orangutan SwissProt: P80220 Pig SwissProt: Q9EQZ1 Rat Unigene: 522074 Human Unigene: 728167 Human Unigene: 22216 Mouse Unigene: 21970 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

糖皮質(zhì)**誘導(dǎo)亮氨酸拉鏈蛋白抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：細胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  

儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來源： Rabbit

外觀： Lyophilized or Liquid

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