Recombinant Human Bcl-2
產(chǎn)品編號
產(chǎn)品名稱
產(chǎn)品包裝
產(chǎn)品價格
XY7257-1mg
1mg
14367.00元
Species
Gene ID
Accession
Source
Length
MW
Tag
Human
596
P10415
E. coli
210aa
23kDa
－
About this Antibody
Name
Recombinant Human Bcl-2 (Recombinant Human B-cell Lymphoma 2; rHuBcl-2)；重組人B細胞**瘤2
Synonyms
apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2
Purity
>95% by SDS-PAGE and HPLC analyses.
Biological Activity
Test in Process.
Physical Appearance
Sterile liquid.
Formulation
0.2μm filtered concentrated solution in 25mM Tris-HCl, pH8.0, 100mM NaCl, 1mM DTT, 30% Glycerol, with Tween-80.
Endotoxin
Less than 0.1EU/μg of rHuBcl-2 as determined by LAL method.
Reconstitution
N/A
Category
Others
Background
B-cell lymphoma 2 (Bcl-2) is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human. Bcl-2 forms homodimer and heterodimers with other Bcl-2 family proteins, like BAX, BAK, BAD and Bcl-xL. Alternative splicing of Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity. Bcl-2 suppresses apoptosis by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In some cases, the presence or absence of Bcl-2 staining in biopsies may be significant for the patient's prognosis or likelihood of cancer relapse. Mature human Bcl-2 shares 88%-90% amino acid sequence identity with murine, rat, bovine, canine Bcl-2.
Amino Acid Sequence
AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD
包裝清單:
包裝
XY7257-5μg
5μg
XY7257-20μg
20μg
XY7257-100μg
100μg
-
說明書
1份
保存條件: -20℃或更低溫度保存，至少一年有效。由于蛋白的每次凍融均會引起部分失活，所以**配制成相應濃度的儲存液后(請根據(jù)產(chǎn)品簡介中Reconstitution一欄的信息配制儲存液)，須分裝后-20℃或更低溫度凍存，以避免反復凍融。 注意事項: 由于有些塑料管壁對某些蛋白有較強的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很難與管壁分離。而載體蛋白(Carrier protein，如0.1% BSA等)的主要作用是預先封閉塑料管壁上的蛋白結合位點，使細胞因子或重組蛋白不會粘附于管壁。所以一定要使用產(chǎn)品簡介中Reconstitution一欄的信息配制儲存液。 本產(chǎn)品**于專業(yè)人員的科學研究用，不得用于臨床診斷或**，不得用于食品或藥品，不得存放于普通住宅內(nèi)。 為了您的**和健康，請穿實驗服并戴一次性手套操作。