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Synonyms
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Blastokinin;
CC10; CC16; CCPBP; CCSP; Clara; PCB-BP; SCGB1A1; UGB; blastokinin; CC10Urine
protein 1; CC16; CCSPCCPBP; Clara cell phospholipid-binding protein; Clara
cells 10 kDa secretory protein; Secretoglobin family 1A member 1;
secretoglobin, family 1A, member 1 (uteroglobin); UGBUP-1; UP1; Urinary
protein 1; uteroglobin
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Background
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Uteroglobin,
also known as secretoglobin family 1A member 1 (SCGB1A1), is encoded by thek
SCGB1A1 gene. Uteroglobin is the founding protein of the secretoglobin
family, whose members are small, secreted, disulfide-bridged dimeric proteins
found in mammals only. Uteroglobin is specifically expressed in clara cells
in the lungs. It is multifunctional and found in various tissues in various
names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL),
blastokinin, clara cell secretory protein (CCSP), clara cell 16 kD protein
(17 in rat/mice), clara Cell-Specific 10 kD protein (CC10), human protein 1,
urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP),
human clara cell phospholipid-binding protein (hCCPBP), secretoglobin 1A
member 1 (SCGB1A1). Its putative functions include immunomodulation,
progesterone binding (weak in some animals, especially weak in humans),
phospholipase A2 inhibitor etc. Murine uteroglobin shares 54% amino acid
sequence identity with human uteroglobin.
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