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Synonyms
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Blastokinin;
CC10; CC16; CCPBP; CCSP; Clara; PCB-BP; SCGB1A1; UGB; blastokinin; CC10Urine
protein 1; CC16; CCSPCCPBP; Clara cell phospholipid-binding protein; Clara
cells 10 kDa secretory protein; Secretoglobin family 1A member 1;
secretoglobin, family 1A, member 1 (uteroglobin); UGBUP-1; UP1; Urinary
protein 1; uteroglobin
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Background
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Uteroglobin,
also known as secretoglobin family 1A member 1 (SCGB1A1), is encoded by thek
SCGB1A1 gene. It is the founding protein of the secretoglobin family, whose
members are small, secreted, disulfide-bridged dimeric proteins found in
mammals only. Uteroglobin is specifically expressed in clara cells in the
lungs. It is multifunctional and found in various tissues in various names
such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin,
clara cell secretory protein (CCSP), clara cell 16 kD protein (17 in
rat/mice), clara Cell-Specific 10 kD protein (CC10), human protein 1, urine
protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human
clara cell phospholipid-binding protein (hCCPBP), secretoglobin 1A member 1
(SCGB1A1). Its putative functions include immunomodulation, progesterone
binding (weak in some animals, especially weak in humans), phospholipase A2
inhibitor etc. Rat uteroglobin shares 55% and 89% amino acid sequence
identity with human and murine uteroglobin, respectively.
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